Sildenafil

Sildenafil By: Jake Formula- C22H30N6O4S Molar Mass- 474.6 g/mol IUPAC Name- 1-[4-ethoxy-3-(6,7-dihydro-1-methyl- 7-oxo-3-propyl-1//H//-pyrazolo[4,3-//d//]pyrimidin-5-yl) phenylsulfonyl]-4-methylpiperazine citrate



__Historical Background__ __Melting Point and Boiling Point__ Melting Point- 189-190 °C Boiling Point- 672.4 °C
 * Created by a group of pharmaceutical chemists working at Pfizer's research facility in England
 * Initially studied for use in [|hypertension] (high blood pressure) and [|angina pectoris] ("severe chest pain", a symptom of [|ischaemic heart disease])
 * First time used, the doctors noticed it had very little affect on angina, but noticed in had an affect on penile erections
 * Pfizer then decided to market it for erectile dysfunction instead of angina
 * The drug was patented in 1996, approved for use in erectile dysfunction by the FDA

__Where is it found/Obtained__ Sildenafil is found in the erectile dysfunction drug Viagra. It is only able to be obtained by prescription from a doctor, so therefore you need a prescription to obtain it. Although it was first used to find a cure for hypertension and angina pectoris, it is only used now for erectile dysfunction. __Uses and Importances__​ Sildenafil is used in the erectile dysfunction drug Viagra. The interesting fact about this though is that it was not first invented for this cause. It was originally invented for the cure for angina pectoris and hypertension. These both have to do with high blood pressure and severe chest pains. When Pfizer (creator of Sildenafil) injected it into his patient, he realized it didn't help ease the pain in the chest, but it caused the patient to develop an erection. From there on out he continued his study on the drug and realized the effect it had on older men, it helped cause their ED.



__Explanation of Structure__

The percent composition of Sildenafil is as follows: C=59.70%, H=6.833%, O=14.46%, and N=18.99% Percent Composition by number is as follows: C=35.48%, H=48.38%, O=9.67%, N=6.45%

__Citations__ Webites Images
 * "Sildenafil". Wikipedia. 11/17/09 [].
 * "Medications and Drugs". MedicineNet. 11/17/09 .
 * "Interactive Molecules". Interactive Library. November 18 .
 * "Sildenafil Citrate". Made-In-China. 11/17/09 .__//
 * //__McDevitt, Conall. " Viagra boost for North – South trade". WordPress. 11/17/09 .