Mitochondrial+Disease

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Mitochondrial Disease



 **The [|mitochondria] makes up of every single cell within your body that contains ** **genetic information. It's known to circulate oxygen as ** **well as convert certain foods  **    **into energy. I ****<span style="font-size: 220%; font-family: Verdana,Geneva,sans-serif"><span style="font-size: 80%; font-family: 'Trebuchet MS',Helvetica,sans-serif">n result, our cells are provided with energy to function  **<span style="font-size: 220%; font-family: Verdana,Geneva,sans-serif"> <span style="font-size: 220%; font-family: Verdana,Geneva,sans-serif"> <span style="font-size: 220%; font-family: Verdana,Geneva,sans-serif"> **<span style="font-size: 220%; font-family: Verdana,Geneva,sans-serif"><span style="font-size: 80%; font-family: 'Trebuchet MS',Helvetica,sans-serif">correctly. The energy **<span style="font-size: 220%; font-family: Verdana,Geneva,sans-serif">  **<span style="font-size: 220%; font-family: Verdana,Geneva,sans-serif"> <span style="font-size: 80%; font-family: 'Trebuchet MS',Helvetica,sans-serif">being produced is known as [|ATP] (Adenosine Triphosphate). Mitochondrial diseases are an example of a lack of energy in which causes the mitochondria to fail. In this case, many children do not survive up to their prime years. This disease is more common in children than adults by far. **

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<span style="font-family: 'Trebuchet MS',Helvetica,sans-serif">**<span style="font-size: 110%; font-family: Verdana,Geneva,sans-serif">This disease affects basically all your major organs along with the rest of your body. Mitoc ** <span style="font-family: 'Trebuchet MS',Helvetica,sans-serif">**<span style="font-size: 110%; font-family: Verdana,Geneva,sans-serif">hondrial disease affects your nervous system by causing seizures, deafness, strokes, and eyesight issues. A person could have cataracts or possibly become blind. The heart can have somethi ** <span style="font-family: 'Trebuchet MS',Helvetica,sans-serif">**<span style="font-size: 110%; font-family: Verdana,Geneva,sans-serif">ng known as a [|conduction block]. A person's kidneys are affected as well as liver failures. A person could experience muscle loss. The digestive tract is affected greatly. You could undergo a series of vomiting with diarrhea. Last but not least, your pancreas could develop you to have diabetes. Overall, the whole body is a target when your fighting against Mitochondrial diseases. **

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<span style="font-family: 'Trebuchet MS',Helvetica,sans-serif">**<span style="font-size: 110%; font-family: Verdana,Geneva,sans-serif">Mitochondrial diseases are known to run through a family's genetics. The genes play a major role in this certain disease. Their function is to p ** <span style="font-family: 'Trebuchet MS',Helvetica,sans-serif">**<span style="font-size: 110%; font-family: Verdana,Geneva,sans-serif">roduce proteins in the mitochondria. The proteins produce an "assembly line" to manufacture the energy (ATP). First, the fats and glucose are drawn into the mitochondria. They are then broken down to produce [|electrons]. At the end of the assembly line, the proteins are known as [|complexes]. The complexes transport the electrons, which is known as the ** <span style="font-family: Verdana,Geneva,sans-serif; font-size: 120%">[|Electron Transport Chain] <span style="font-family: 'Trebuchet MS',Helvetica,sans-serif">**<span style="font-size: 110%; font-family: Verdana,Geneva,sans-serif">. ([|Video of the Electron Transport Chain]) This would create ATP synthase. ATP synthase is when an enzyme creates ATP from ADP and phosphate by using energy. The energy is basically made up of mostly protons, which is the positive charge molecules. **  <span style="font-family: 'Trebuchet MS',Helvetica,sans-serif"><span style="font-size: 110%; font-family: Verdana,Geneva,sans-serif">

<span style="font-size: 220%; font-family: Verdana,Geneva,sans-serif">*Treatment*

 * <span style="font-size: 120%; font-family: 'Trebuchet MS',Helvetica,sans-serif">Mitochondrial diseases are very hard to be treated, but the risks can be reduced. Everyone is declared "biochemically different." Therefore treatment is much different for people. Physical therapy would be prescribed with enzyme or vitamin therapies. But, there are many supplements that could possibly help such as, CoenzymeQ10, Vitamin E, Vitamin C, and many other antioxidants. However, [|Pyruvate] is very common to reduce the side effects for mitochondrial diseases. **

-Types-
-This occurs in young adults which happens to impair their vision. -This disease is very rare with great effects on the nervous systems. Some people develop this disease due to their family genetics. The mutations may lead to death. There is currently no cure for this, but scientists are hoping to determine one for future references. <span style="font-family: 'Trebuchet MS',Helvetica,sans-serif"> **
 * <span style="font-family: 'Trebuchet MS',Helvetica,sans-serif"> <span style="font-family: 'Trebuchet MS',Helvetica,sans-serif">  There are many types of Mitochondrial diseases such as:
 * DAD([|Diabetes Mellitus and Deafness])
 * LHON(Leber's Hereditary Optic Neuropathy)
 * [|Wolff-Parkinson-White Syndrome]
 * [|Leigh Disease]

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<span style="font-size: 220%; font-family: Verdana,Geneva,sans-serif"> http://www.mda.org/publications/mitochondrial_myopathies.html http://www.clevelandclinic.org/health/health-info/docs/1600/1678.asp?index=6957 http://www.umdf.org/site/c.dnJEKLNqFoG/b.3042169/ [|http://www.en.wikipedia.org/] http://www.google.com http://www.dentistry.leeds.ac.uk/biochem/lecture/etran/etran.htm http://rarediseases.about.com/cs/mitochondrialdis/a/062103.htm http://www.tsbvi.edu/Outreach/seehear/spring02/mitochondrial.htm

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