Cystic+Fibrosis

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 * Cystic Fibrosistoc

By Maddie Gilmore

**Introduction **
Cystic Fibrosis (CF) is a progressive genetic disease that affects the airways of the lungs. It also can affect the pancreas, kidneys, and reproductive organs. Both parents have to carry a defective gene for it to be passed on to their child. The mutation of the gene is found on chromosome 7. The defective gene affects the production of the protein cystic fibrosis transmembrane conductance regulator (CFTR) which helps regulate the mucus, sweat, saliva, tears, and digestive enzymes of the body. People with Cystic Fibrosis do not have adequate amounts of (CFTR) because the body destroys the deformed protein.



**Symptoms **
Mucus filled airways of the lungs Chronic coughing and wheezing Persistent lung infections Skin that tastes salty Growth and weight issues Male infertility Digestive Issues



**Statistics **
If both parents are carriers:
 * 1) 25 % chance that their child will have CF
 * 2) <span style="color: #201dd4; font-family: Georgia,serif; font-size: 150%;">25% chance that their child will not have CF
 * 3) <span style="color: #201dd4; font-family: Georgia,serif; font-size: 150%;">50 % chance that their child will be a carrier but not have CF

<span style="color: #201dd4; font-family: Georgia,serif; font-size: 150%;">Life expectancy in 1980- 14 years <span style="color: #201dd4; font-family: Georgia,serif; font-size: 150%;">Life expectancy in 2015- 37.5 years <span style="color: #201dd4; font-family: Georgia,serif; font-size: 150%;">Most commonly found in Caucasian people <span style="color: #201dd4; font-family: Georgia,serif; font-size: 150%;">One in thirty Americans are carriers <span style="color: #201dd4; font-family: Georgia,serif; font-size: 150%;">There are over 1,700 gene mutations for Cystic Fibrosis.

**<span style="color: #201dd4; font-family: Georgia,serif; font-size: 150%;">Diagnosis **
<span style="color: #201dd4; font-family: Georgia,serif; font-size: 150%;">Genetic testing <span style="color: #201dd4; font-family: Georgia,serif; font-size: 150%;">Sweat testing <span style="color: #201dd4; font-family: Georgia,serif; font-size: 150%;">Sputum testing <span style="color: #201dd4; font-family: Georgia,serif; font-size: 150%;">Chest X-rays

**<span style="color: #201dd4; font-family: Georgia,serif; font-size: 150%;">Treatments **
<span style="color: #201dd4; font-family: Georgia,serif; font-size: 20px;">There is currently no cure for Cystic Fibrosis but there are therapies and medications to help prolong life expectancy and alleviate some of the symptoms.

__<span style="color: #201dd4; font-family: Georgia,serif; font-size: 20px;">Medications: __ <span style="color: #201dd4; font-family: Georgia,serif; font-size: 20px;">Mucus thinners <span style="color: #201dd4; font-family: Georgia,serif; font-size: 20px;">Antibiotics <span style="color: #201dd4; font-family: Georgia,serif; font-size: 20px;">Bronchodilators <span style="color: #201dd4; font-family: Georgia,serif; font-size: 20px;">Digestive enzymes <span style="color: #201dd4; font-family: Georgia,serif; font-size: 20px;">Anti-inflammatory medications

__<span style="color: #201dd4; font-family: Georgia,serif; font-size: 20px;">Therapies: __ <span style="color: #201dd4; font-family: Georgia,serif; font-size: 20px;">Physical therapy of the chest <span style="color: #201dd4; font-family: Georgia,serif; font-size: 20px;">Oxygen therapy <span style="color: #201dd4; font-family: Georgia,serif; font-size: 20px;">CFTR Modulator Therapy will help with select gene mutations <span style="color: #201dd4; font-family: Georgia,serif; font-size: 20px;">Lung transplant

**<span style="color: #201dd4; font-family: Georgia,serif; font-size: 20px;">Videos **
<span style="color: #201dd4; font-family: Georgia,serif; font-size: 20px;">media type="youtube" key="xkBMesSJeHs" width="560" height="315"

media type="youtube" key="BhFpFiZumS0" width="560" height="315"

** Citations **
National Institutes of Health. U.S. Department of Health and Human Services, 13 Dec. 2013. Web. 22 Feb. 2017 "Cystic fibrosis and the basic problem." Cystic fibrosis and the basic problem. Leeds Regional Adult and Pediatric Cystic Fibrosis, Apr. 2008. Web. 22 Feb. 2017 "Cystic Fibrosis Foundation." About Cystic Fibrosis | CF Foundation. N.p., n.d. Web. 22 Feb. 2017 Wpadmin. "17 Amazing Cystic Fibrosis Life Expectancy Statistics." HRFnd. N.p., 27 Jan. 2015. Web. 22 Feb. 2017 2016 Cystic Fibrosis Foundation Video. YouTube, 02 Feb. 2016. Web. 23 Feb. 2017 Cystic fibrosis - causes, symptoms, diagnosis, treatment & pathology. YouTube, 31 Aug. 2016. Web. 23 Feb. 2017

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