Ibuprofen

=**IBUPROFEN** = =  = = =

= = = = = = = = = = = = = = = = = = = = = = = = = = = = = FORMULA - = =C13H18O2 = = = = = =**Molar Mass- **=

=206.3 g/mol =





= Chemical and physical Properties: =

 **<span style="font-size: 120%; color: rgb(30, 0, 0)">I <span style="font-size: 120%; color: rgb(24, 1, 1)">buprofen is a part of the propanoic acid group of NSAID's. It is unsoluable in water but is soluable in ethanol and acetone. It is an aromatic compound containing a benzene ring. In the upper right of the structure is a carboxylic, propanoic acid. Attached to the second carbon is a phenyl group. Attached to the phenyl group, para to the propionic acid group, is an isobutyl group from which the Name "Ibuprofen is derived". The compound is a rather small organic compound composed of 13 carbon atoms, 18 hydrogen atoms, and 2 oxygen atoms. At standard temperature and pressure it is a crystalline solid with a white/off-white color. The following are the physical properties of Ibuprofen <span style="color: rgb(0, 0, 0); font-family: 'Courier New',Courier,monospace"><span style="display: block; color: rgb(0, 0, 0); font-family: 'Courier New',Courier,monospace; text-align: left"><span style="font-size: 160%; color: rgb(0, 0, 0); font-family: 'Courier New',Courier,monospace">   ** <span style="font-size: 130%; color: rgb(20, 0, 0)">  <span style="display: block; font-size: 190%; color: rgb(0, 255, 0); font-family: 'Courier New',Courier,monospace; text-align: center">**<span style="color: rgb(18, 245, 15); font-size: 70%"> Density **<span style="color: rgb(25, 0, 0); font-size: 70%"><span style="font-family: 'Courier New',Courier,monospace"><span style="color: rgb(0, 1, 5); font-size: 80%">. 4g/cm³ <span style="display: block; font-size: 130%; color: rgb(0, 0, 0); font-family: 'Courier New',Courier,monospace; text-align: center">**<span style="font-size: 130%; color: rgb(0, 0, 0)"><span style="color: rgb(11, 234, 18)"> Melting Point 157° C **

<span style="display: block; font-size: 190%; color: rgb(0, 255, 0); font-family: 'Courier New',Courier,monospace; text-align: center">**Boiling Point <span style="font-size: 90%; color: rgb(0, 0, 0)">215° C ** <span style="display: block; font-size: 190%; color: rgb(0, 255, 0); font-family: 'Courier New',Courier,monospace; text-align: center">**Percent Composition by Mass** <span style="display: block; font-size: 130%; color: rgb(0, 0, 0); font-family: 'Courier New',Courier,monospace; text-align: center">** 75.69% C, 8.80% H, 15.51% O

<span style="font-size: 120%; color: rgb(0, 255, 0)">Percent Composition by Number 39% C, 55% H, 6% O **

= = =<span style="display: block; font-size: 150%; color: rgb(0, 255, 0); font-family: 'Courier New',Courier,monospace; text-align: center">Type of bonding = = = <span style="display: block; font-size: 140%; color: rgb(0, 0, 0); font-family: 'Courier New',Courier,monospace; text-align: center">** Covalent bond (sharing of pairs of electrons between atoms) **

** Molecular Geometry **

<span style="display: block; font-size: 200%; color: rgb(55, 242, 13); font-family: 'Courier New',Courier,monospace; text-align: center">**<span style="display: block; color: rgb(0, 255, 0); font-family: 'Courier New',Courier,monospace; text-align: center">A brief history of Ibuprofen ** <span style="font-size: 150%; font-family: 'Courier New',Courier,monospace">
 * Ibuprofen was discovered by the research department of BOOTS group, a Pharmaceutical research group during the 1950's by Stewart Adams, John Nicholson, and Colin Burrows. The need had arisen for a safer rheumatoid arthritis drug. Preexisting drugs had risky side effects. It was created as a pain and fever-relieving drug. Studies had been conducted in a research wing of the BOOTS pharmaceuticals group on the effects of similar compounds and in 1959 Ibuprofen was discovered. The drug was first made publicly available in 1969 and it hit the United States market in 1974. Since then it has had over one hundred trade names such as Advil, Motrin, and the less popular Canadian Novo-Profen**

<span style="display: block; font-size: 200%; color: rgb(12, 218, 7); font-family: 'Courier New',Courier,monospace; text-align: center">**<span style="display: block; color: rgb(0, 255, 0); font-family: 'Courier New',Courier,monospace; text-align: center">HOW IT WORKS- **

=
<span style="font-family: 'Courier New',Courier,monospace">**<span style="font-size: 150%; font-family: 'Courier New',Courier,monospace">Ibuprofen is an NSAID (non-steroidal anti-inflammatory drug). It works through inhibition of cyclooxegenase, an enzyme responsible for formation of important biological mediators called prostanoid, which control inflammatory and anaphylactic chemical reactions. Ibuprofen bonds non-covalently to the Cyclooxygenase enzyme and competes with its substrate. ** **<span style="font-size: 150%; font-family: 'Courier New',Courier,monospace"> In other words, it inhibits the reactions that cause swelling, pain, and fever and thus relieves the pain that you feel. One of the reasons that Ibuprofen is so popular worldwide is because of its low level of side effects and dependency. ** ======

<span style="font-size: 150%; font-family: 'Courier New',Courier,monospace">
<span style="font-size: 150%; font-family: 'Courier New',Courier,monospace"> <span style="display: block; font-size: 200%; color: rgb(0, 255, 0); font-family: 'Courier New',Courier,monospace; text-align: center"> <span style="color: rgb(0, 0, 0); font-family: 'Courier New',Courier,monospace"><span style="display: block; color: rgb(0, 0, 0); font-family: 'Courier New',Courier,monospace; text-align: left"><span style="display: block; font-size: 120%; color: rgb(0, 0, 0); font-family: 'Courier New',Courier,monospace; text-align: left">** Ibuprofen is used daily by millions of people worldwide and can now be found in many stores and under many trade names. It is sold over the counter, but usually in smaller doses of about 200mg. People take Ibuprofen to settle many types of aches or pains. Most of the time it is taken in doses of 400mg to 800mg at a time. Ibuprofen is not a naturally occurring compound, it is synthesized. The process for synthesis of Ibuprofen is described further [|here] ** <span style="display: block; color: rgb(0, 255, 0); font-family: 'Courier New',Courier,monospace; text-align: center"> <span style="display: block; font-size: 200%; color: rgb(0, 255, 0); font-family: 'Courier New',Courier,monospace; text-align: center"> <span style="color: rgb(0, 0, 0); font-family: 'Courier New',Courier,monospace"><span style="display: block; color: rgb(0, 0, 0); font-family: 'Courier New',Courier,monospace; text-align: left"><span style="font-size: 160%; color: rgb(0, 0, 0); font-family: 'Courier New',Courier,monospace"> <span style="display: block; font-size: 190%; color: rgb(0, 255, 0); font-family: 'Courier New',Courier,monospace; text-align: center">**Uses and Importance of Ibuprofen** <span style="font-size: 140%; color: rgb(0, 0, 0); font-family: 'Courier New',Courier,monospace"> **Ibuprofen is an effective analgesic (pain relieving) and anti-pyretic (fever reducing) pharmaceutical drug. It is proven to work quickly and effectively to relieve pain from almost anywhere in the body. Its most common use is as a reliever for fever symptoms, menstrual cramps, headaches, arthritis, and many other common pains. It is used daily by many** **people to get on with their lives without pain or aching. Ibuprofen is available over the counter and also in larger doses under prescription.** <span style="display: block; font-size: 190%; color: rgb(0, 255, 0); font-family: 'Courier New',Courier,monospace; text-align: center">
 * Where is it found? And how is it obtained?**

<span style="color: rgb(18, 245, 15); font-size: 70%">  <span style="display: block; font-size: 140%; color: rgb(0, 0, 0); font-family: 'Courier New',Courier,monospace; text-align: center">

<span style="display: block; font-size: 150%; color: rgb(0, 255, 0); font-family: 'Courier New',Courier,monospace; text-align: center">** Sites used: ** <span style="font-family: 'Courier New',Courier,monospace; text-align: center; display: block">[|http://en.wikipedia.org/wiki/Ibuprofen</span]> __www.chemistryexplained.com/Hy-Kr/Ibuprofen.html__

[|www.springerlink.com/content/144080032646xk07] http://www.chemistryexplained.com/Hy-Kr/Ibuprofen.html

http://www.wcer.wisc.edu/step/ep301/Spr2000/esselman/IBUb.html

http://www.ibuprofen-foundation.com/what-ibuprofen/documents/TIIbuprofen.pdf

http://www.tootoo.com/supplier/product-detail/8510343/Ibuprofen_(Metronidaazole__Trimethoprim).html


 * //*Created by: Brittany and Ian*//**