IBUPROFEN


ibuprofendontsueme.JPG
FORMULA -

C13H18O2

Molar Mass-


206.3 g/mol









i mol 3-D image of Ibuprofen



IBUPROFEN


Chemical and physical Properties:


Ibuprofen is a part of the propanoic acid group of NSAID's. It is unsoluable in water but is soluable in ethanol and acetone. It is an aromatic compound containing a benzene ring. In the upper right of the structure is a carboxylic, propanoic acid. Attached to the second carbon is a phenyl group. Attached to the phenyl group, para to the propionic acid group, is an isobutyl group from which the Name "Ibuprofen is derived". The compound is a rather small organic compound composed of 13 carbon atoms, 18 hydrogen atoms, and 2 oxygen atoms. At standard temperature and pressure it is a crystalline solid with a white/off-white color. The following are the physical properties of Ibuprofen

Density
.4g/cm³

Melting Point
157° C


Boiling Point
215° C


Percent Composition by Mass75.69% C, 8.80% H, 15.51% O


Percent Composition by Number
39% C, 55% H, 6% O



Type of bonding

Covalent bond (sharing of pairs of electrons between atoms)


Molecular Geometry
Ibuprofen-3D-balls.png

A brief history of Ibuprofen
Ibuprofen was discovered by the research department of BOOTS group, a Pharmaceutical research group during the 1950's by Stewart Adams, John Nicholson, and Colin Burrows. The need had arisen for a safer rheumatoid arthritis drug. Preexisting drugs had risky side effects. It was created as a pain and fever-relieving drug. Studies had been conducted in a research wing of the BOOTS pharmaceuticals group on the effects of similar compounds and in 1959 Ibuprofen was discovered. The drug was first made publicly available in 1969 and it hit the United States market in 1974. Since then it has had over one hundred trade names such as Advil, Motrin, and the less popular Canadian Novo-Profen


HOW IT WORKS-
Ibuprofen is an NSAID (non-steroidal anti-inflammatory drug). It works through inhibition of cyclooxegenase, an enzyme responsible for formation of important biological mediators called prostanoid, which control inflammatory and anaphylactic chemical reactions. Ibuprofen bonds non-covalently to the Cyclooxygenase enzyme and competes with its substrate. In other words, it inhibits the reactions that cause swelling, pain, and fever and thus relieves the pain that you feel. One of the reasons that Ibuprofen is so popular worldwide is because of its low level of side effects and dependency.


Where is it found? And how is it obtained?

Ibuprofen is used daily by millions of people worldwide and can now be found in many stores and under many trade names. It is sold over the counter, but usually in smaller doses of about 200mg. People take Ibuprofen to settle many types of aches or pains. Most of the time it is taken in doses of 400mg to 800mg at a time. Ibuprofen is not a naturally occurring compound, it is synthesized. The process for synthesis of Ibuprofen is described further here


Uses and Importance of Ibuprofen
Ibuprofen is an effective analgesic (pain relieving) and anti-pyretic (fever reducing) pharmaceutical drug. It is proven to work quickly and effectively to relieve pain from almost anywhere in the body. Its most common use is as a reliever for fever symptoms, menstrual cramps, headaches, arthritis, and many other common pains. It is used daily by many people to get on with their lives without pain or aching. Ibuprofen is available over the counter and also in larger doses under prescription.






Sites used:
http://en.wikipedia.org/wiki/Ibuprofen</span>

www.chemistryexplained.com/Hy-Kr/Ibuprofen.html

www.springerlink.com/content/144080032646xk07

http://www.chemistryexplained.com/Hy-Kr/Ibuprofen.html

http://www.wcer.wisc.edu/step/ep301/Spr2000/esselman/IBUb.html

http://www.ibuprofen-foundation.com/what-ibuprofen/documents/TIIbuprofen.pdf

http://www.tootoo.com/supplier/product-detail/8510343/Ibuprofen_(Metronidaazole__Trimethoprim).html






*Created by: Brittany and Ian*