Meryn

Introduction

What is Hyperoxaluria? It is a condition in which case you have too much oxalate in your urine. Oxalate is a naturally occurring chemical in your body, and is also in certain foods. Oxalate or ehtanedioate has the formula C2O4)2-. Your body has no need for it, so it is usually just eliminated as waste through your kidneys. Too much oxalate in our urine can cause problems when the excess oxalate binds with the calcium and forms kidney stones.
18071572_ml-225x300.jpg

Causes
There are three types of hyperoxaluria based upon how you contract it. There is dietary hyperoxaluria which is caused by eating many foods high in oxalate such as rhubarb, okra, leeks, spinach, beets, and Swiss chard. Enteric hyperoxaluria can be caused by several intestinal diseases such as Crohn's diseases, increasing the absorption of oxalate from foods. Primary hyperoxaluria (PH) is a rare, inherited genetic disorder of liver metabolism that can do severe damage to your kidneys.
oxalate.gif

Molecular Basis of PH

PH is incredibly rare, and only occurs in three out of one million people. In this type of hyperoxaluria, the liver doesn't produce enough of a certain enzyme to prevent overproduction of oxalate. There are three types of PH, with three different enzymes not working, therefore causing in increase in oxalate production. They are as follows:
PH 1: alanine-glyoxylate aminotransferase, or AGT
PH 2: glyoxalate/hydroxypruvate reductase, or GR/HPR
PH 3: 4-hydroxy-2-oxoglutarate aldolase, or HOGA
When there is not enough of these enzymes or they are not working properly, the body produces very high amounts of oxalate which combines with calcium and creates kidney stones.

Symptoms
  • Kidney Stones
    • Severe or sudden abdominal flank pain
    • Blood in the urine
    • Frequent urge to urinate
    • Pain when urinating
    • Fever and chills
    • Kidney failure

Treatments

Reducing oxalate by means of medication, high fluid intake, and dietary modifications are all apart of the treatment process. B-6 vitamins reduce the amount of oxalate in your body.

Video

https://www.youtube.com/watch?v=CDUH-MWcOqM

Works Cited

http://ohf.org/wp-content/uploads/2015/02/18071572_ml-225x300.jpg
http://www.mayo.edu/research/~/media/kcms/gbs/research/images/2013/03/07/12/50/oxalate.gif
http://ohf.org/treatment/