Gilbert's Syndrome

By: Sara White

Table of Contents:

About Gilbert's Syndrome

  • Definition
  • Causes of Gilbert's Syndrome

Molecular Description

  • Enzymes


Gilbert's Syndrome is a chronic and mild liver disorder when bilirubin, a waste product produced from the breakdown of red blood cells, is not properly processed by the liver. When the bilirubin is not properly processed by the liver, this causes toxins to remain within the body.

Causes of Gilbert's Syndrome

Gilbert's Syndrome is a disease that is hereditary. It is caused by an abnormal gene that controls the enzyme that aids in the breakdown and removal of bilirubin. Due to this abnormal gene, the essential enzyme,s production rate slows and becomes rare within the body. This causes unconjugated bilirubin to build up within the bloodstream.

Molecular Description

Within the body, there is a two-phase detoxication process that occurs. Gilbert's Syndrome effects of the phase called the glucuronidation system.


The enzymes in the glucuronidation system are called diphosphate glucuronyl transferase also known as UGT. A specific enzyme effected in Gilbert's Syndrome is UGT1A1. This is the enzyme that breaks down and removes bilirubin. Two more enzymes that are u effected are UGT1A6 and UGT1A7.